cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl,
-ˌsōl,
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
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While prior research had documented higher cortisol levels on weekdays compared to weekends, this study is the first to isolate Monday as uniquely disruptive. Melissa Fleur Afshar, MSNBC Newsweek, 6 July 2025 Foods and supplements and practices for balancing that cortisol! Ana Morales, Vogue, 5 July 2025 While humans need cortisol to live and a certain level of stress can support personal growth, elevated cortisol levels can be an indicator of chronic stress. Renée Onque, CNBC, 3 July 2025 Some people may see their symptoms improve after trying cortisol cocktails thanks to the placebo effect. Maggie O'Neill, Verywell Health, 2 July 2025 See All Example Sentences for cortisol

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

Browse Nearby Words

Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://x0upouf933.proxynodejs.usequeue.com/dictionary/cortisol. Accessed 12 Jul. 2025.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

More from Merriam-Webster on cortisol

Last Updated: - Updated example sentences
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